Yanhua CHEN
Associate Professor, Master Supervisor, College of Life and Environmental Sciences, Minzu University of China
Deputy Director, Key Laboratory of Mass Spectrometry Imaging and Metabolomics (State Ethnic Affairs Commission)
Education:
(1) 2006.09 to 2009.07, Pharmaceutical Analysis, Peking Union Medical College, PhD
(2) 2003-09 to 2006-07, Biochemistry and Molecular Biology, Jilin University, Master degree
(3) 1999-09 to 2003-07, Jilin University, Pharmacy, Bachelor degree
Academic experience:
(1) From June 2019 till now, Associate Professor, School of Life and Environmental Sciences, Minzu University of China
(2) July 2014 to May 2019, Associate Professor, Institute of Materia Medica, Chinese Academy of Medical Sciences
(3) September 2009 to June 2014, Assistant Professor, Institute of Materia Medica, Chinese Academy of Medical Sciences
Main research interests: Mass Spectrometry-based metabolomics method and its application in diseases and pharmaceutical analysis.
More than 50 papers have been published in Analytical Chemistry, Chinese chemical letters, Journal of pharmaceutical analysis, Analytica Chimica Acta, etc.
The first prize of the Science and Technology Award of China Association for Instrumental Analysis (CAIA Award) (second finisher).
A member of the Metabolomics Branch of the Chinese Biophysical Society, a member of the Cancer Metabolism and Therapy Committee of the Chinese Medical Doctor Association, a member of the pharmacy committee of the Chinese Women Medical Doctor Association, and a member of the Beijing Mass Spectrometry Society.
The journal reviewer of Analytical Chemistry, Chinese chemical letters, Analytica Chimica Acta, Talanta, et al.
Representative articles:
1. Yanhua Chen, Xian Ding, Jun Zhou, Zhaoying Wang, Yunhai Bo, Ying Hu, Qingce Zang, Jing Xu, Ruiping Zhang, Jiuming He, Fen Yang*, Zeper Abliz*. Plasma metabolomics combined with mass spectrometry imaging reveals crosstalk between tumor and plasma in gastric cancer genesis and metastasis. Chinese Chemical Letters. 2025, 36: 110351. JCR分区：Q1；IF=9.4
2. Qian Li, Jinpeng Bai, Yuxue Ma, Yu Sun, Wenbin Zhou, Zhaoying Wang, Zhi Zhou, Zhonghua Wang, Yanhua Chen*, Zeper Abliz*. Pharmacometabolomics and mass spectrometry imaging approach to reveal the neurochemical mechanisms of Polygala tenuifolia. J Pharm Anal. 2024, 14(7):100973. JCR分区：Q1；IF=8.8
3. Xian Ding, Fen Yang, Yanhua Chen*, Jing Xu, Jiuming He, Ruiping Zhang, Zeper Abliz*. NormISWSVR: A Data Integration and Normalization Approach for Large-Scale Metabolomics. Analytical Chemistry, 2022, 94: 7500-7509. JCR分区：Q1；IF=8.0
4.Yanhua Chen，Yanhua Chen, Qianlun Pu, Fengting Yu, Xian Ding, Yu Sun, Qinglan Guo, Jiangong Shi, Jianjun Zhang*, Zeper Abliz*. Comprehensive quantitative method for neurotransmitters to study the activity of a sedative-hypnotic candidate using microdialysis and LC×LC-MS/MS. Talanta, 2022, 245: 123418. JCR分区：Q1；IF=6.55
5. Junyao Zhou , Mingmin Qian, Chenxi Li, Wenbin Zhou, Lan Yao, Yanhua Chen*, Zeper Abliz*. Metabolomics and integrated network pharmacology analysis reveal that ginkgolides act as potential active anticancer components by regulating one-carbon metabolism. J Ethnopharmacol. 2022, 298:115609. JCR分区：Q1；IF=5.4
6. Zhi Zhou, Yanhua Chen*, Gao Yang, Nan Bi, Xiaofei Yue, Jiuming He, Ruiping Zhang, Lvhua Wang , Zeper Abliz*. Development of a high-coverage metabolome relative quantitative method for large-scale sample analysis. Anal Chim Acta., 2020, 1109: 44-52. JCR分区：Q1；IF=6.91
7. Han Liao, Qingce Zang, Qinglin Lv, Yang Gao, Zitong Zhao, Jiuming He, Ruiping Zhang, Yongmei Song,Yanhua Chen*, Zeper Abliz. Development of methionine methylation profiling and relative quantification in human breast cancer cells based on metabolic stable isotope labeling.
Analyst. 2019, 144(13):3988-3998. JCR分区：Q1；IF=5.22
8. Xiaofei Yue, Jiuming He, Ruiping Zhang, Jing Xu, Zhi Zhou, Rui Zhang, Nan Bi, Zhonghua Wang, Chenglong Sun, Luhua Wang, Yanhua Chen*, Zeper Abliz* (Co-Corresponding author).Biotransformation-based metabolomics profiling method for determining and quantitating cancer-related metabolites. Journal of Chromatography A, 2018, 1580, 80–89. JCR分区：Q1；IF=4.76
9. Yang Gao, Yanhua Chen*, Xiaofei Yue, Jiuming He, Ruiping Zhang, Jing Xu, Zhi Zhou, Zhonghua Wang, Rui Zhang, Zeper Abliz*. Development of simultaneous targeted metabolite quantification and untargeted metabolomics strategy using dual-column liquid chromatography coupled with tandem mass spectrometry. Anal Chim Acta., 2018, 1037:369-379. JCR分区：Q1；IF=6.91
10. Yanhua Chen#, Zhi Zhou#, Wei Yang, Nan Bi, Jing Xu, Jiuming He, Ruiping Zhang, Lvhua Wang, Zeper Abliz*. Development of a Data-Independent Targeted Metabolomics Method for Relative Quantification Using Liquid Chromatography coupled with Tandem Mass Spectrometry. Anal. Chem., 2017, 89 (13) :6954-6962. JCR分区：Q1；IF=8.0
11. Yanhua Chen, Zeper Abliz*. Mass spectrometry in metabolomics: what lies ahead. Bioanalysis, 2017, 9(2): 155-157. JCR分区：Q2；IF=2.81
12. Zhi Zhou, Yanhua Chen*, Jiuming He, Jing Xu, Ruiping Zhang, Yan Mao, Zeper Abliz. Systematic evaluation of serum and plasma collection on the endogenous metabolome. Bioanalysis, 2017, 9:239-250. JCR分区：Q2；IF=2.81
13. Yanhua Chen#, Jing Xu#, Ruiping Zhang, Zeper Abliz*. Methods used to increase the comprehensive coverage of urinary and plasma metabolomes by MS. Bioanalysis. 2016, 8(9): 981-997. JCR分区：Q2；IF=2.81.
14. Yanhua Chen, Guoqing Shen, Ruiping Zhang, Jiuming He, Yi Zhang, Jing Xu, Wei Yang, Xiaoguang Chen, Yongmei Song, Zeper Abliz*. Combination of Injection Volume Calibration by Creatinine and MS Signals’Normalization to Overcome Urine Variability in LC-MS-Based Metabolomics Studies. Anal. Chem.,2013, 85: 7659−7665. JCR分区：Q1；IF=8.0
15. Yanhua Chen, Jing Xu, Ruiping Zhang, GuoqingShen, Yongmei Song, Jianghao Sun, Jiuming He, Qimin Zhan, Zeper Abliz*. Assessment of data pre-processing methods for LC-MS/MS-based metabolomics of uterine cervix cancer. Analyst, 2013, 138: 2669-2677. JCR分区：Q1；IF=5.22
16. Jing Xu#, Yanhua Chen#, Ruiping Zhang, Yongmei Song, Jianzhong Cao, Nan Bi, Jingbo Wang, Jiuming He, Jinfa Bai, Lijia Dong, Luhua Wang, Qimin Zhan, Zeper Abliz*. Global and Targeted Metabolomics of Esophageal Squamous Cell Carcinoma Discovers Potential Diagnostic and Therapeutic Biomarkers. Mol Cell Proteomics, 2013, 12: 1306-1318. JCR分区：Q1；IF=7.38
