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Xiaodong WANG

Publish By ： Hits： Published：2024/12/20


Xiaodong WANG

Title: Professor, PhD Supervisor

Email:Xiaodong@muc.edu.cn

Individual Homepage:https://www.researchgate.net/profile/Xiaodong_Wang21

Ph.D. in Science (Tsinghua University - Peking Union Medical College), Professor, and Ph.D. Supervisor. Selected for the "Young and Middle-Aged Talent Cultivation Program" by the National Ethnic Affairs Commission of the People's Republic of China. Recognized as a High-Level Outstanding Talent and Academic Leader at Minzu University of China.

Current Positions:

  • Deputy Director, Key Laboratory of Mass Spectrometry Imaging and Metabolomics, National Ethnic Affairs Commission

  • Member, Committee on Plant Integrative Omics, Botanical Society of China

  • Project Review Expert, National Natural Science Foundation of China (NSFC)

  • Expert in Graduate Education Evaluation and Monitoring (Master's/Ph.D. Dissertation Reviewer, Ministry of Education)

  • Review Expert, HICOOL Global Entrepreneurship Competition

  • Project Review Expert, Beijing Overseas High-Level Talent Association

  • Associate Editor, Frontiers in Plant Science (Top Journal in Plant Science)

  • Peer Reviewer for over 20 prestigious international journals, including Nature Methods, Nature Metabolism, Nature Communications, Nature Protocols, Trends in Plant Science, TrAC - Trends in Analytical Chemistry, Trends in Food Science & Technology, Molecular & Cellular Proteomics, Analytical Chemistry, Chinese Chemical Letters, and Food Chemistry.

Previous Positions:

  • Research Scientist & Postdoctoral Fellow, University of Victoria - Genome BC Proteomics Centre, Canada (2012–2015)

  • Research Scientist, Metabolomics Innovation Centre (TMIC) & Science and Technology Innovation Centre (STIC), Canada (2012–2015)

Professional Memberships:

  • Member of the Human Proteome Organization (HUPO)

  • Member of the American Society for Mass Spectrometry (ASMS)

  • Member of the American Chemical Society (ACS)

  • Member of the Canadian National Proteomics Network (CNPN)

  • Member of the Canadian Society for Chemistry (CSC)

Awards and Honors:

  • 2024: National First Prize, CULSC 9th National Undergraduate Life Science Competition, "Toxic Spatial Omics Study of Zebrafish Exposed to Emerging Pollutant OBS Based on MALDI-MSI" (Advisor).

  • 2024: National Third Prize, CULSC 9th National Undergraduate Life Science Competition, "Molecular Characterization Study of Breast Cancer Based on MALDI-MSI Spatial Omics" (Advisor).

  • 2024: First Prize and Second Prize, 10th Beijing Undergraduate Biology Competition (Advisor).

  • 2022: Excellent Advisor, Beijing Outstanding Undergraduate Thesis Award, "Development of a Novel MALDI-MSI Method for In Situ Detection and Imaging of Endogenous Proteins in FFPE Tissue Sections".

  • 2020: Outstanding Contribution Award, Journal of Proteomics.

  • 2014: Young Investigator Award, 6th Annual CNPN Symposium, Canada.

  • 2012: Beijing Outstanding Graduate Award.

  • 2009: Excellent Paper Award, ACTA Biophysica Sinica.

Courses Taught:

Undergraduate:

  • Modern Instrumental Analysis (54 hours)

  • Proteomics (36 hours)

  • Frontiers in Life Sciences (2 hours, taught once per cohort)

  • Scientific Literature Search and Writing (54 hours)

Graduate:

  • Advances in Modern Instrumental Analysis in Biology (36 hours)

  • Guidance on Graduate Thesis Writing (18 hours)

  • Introduction to Omics Research (36 hours)

Research Fields and Topics

Research Fields:

  • Mass Spectrometry Imaging

  • Proteomics

  • Metabolomics

  • Analytical Chemistry

Research Topics:

I. Biological Imaging:
Development and application of new technologies and methods for MALDI/ESI mass spectrometry imaging (MSI):

  • Developing novel MALDI matrices to enhance the efficiency of MALDI tissue imaging for endogenous biomolecules (e.g., small metabolites, lipids, energy metabolism products, nucleotides, amino acids, peptides, and proteins).

  • Researching new technologies for qualitative/quantitative MSI of tissue-specific protein post-translational modifications.

  • Coupling novel MSI techniques with liquid chromatography-mass spectrometry (LC-MS) for applications in screening bioactive compounds from medicinal plants, monitoring drug dynamics, elucidating therapeutic mechanisms, and identifying biomarkers for chronic diseases and early diagnosis.

  • Conducting spatial proteomics/metabolomics/lipidomics studies based on medicinal and edible plants.

  • Developing and applying 3D MSI techniques.

  • Creating and applying novel single-cell MALDI MSI technologies.

II. Proteomics:
Developing and applying novel methods and technologies for proteomics of plant and animal samples:

  • Investigating innovative analytical methods for protein complexes and protein-protein interactions.

  • Qualitative and quantitative research on post-translational modifications (e.g., glycosylation, phosphorylation, methylation, acetylation).

  • Conducting membrane proteomics studies of plants and animals.

  • Applying advanced proteomics technologies for personalized diagnostics and biomarker discovery in chronic diseases.

Research Projects:

  • General Program of the National Natural Science Foundation of China: Study on the Mechanisms of Seed Dormancy and Germination in the Endangered Relict Plant Taxus Chinensis var. mairei Based on Proteomics and Mass Spectrometry In Situ Imaging Technology (Project No. 31770384) (Principal Investigator).

  • Youth Science Fund Project, National Natural Science Foundation of China: Development of Novel Open-Source MALDI/DESI Dual-Source Complementary Mass Spectrometry Imaging Technology and Its Application in Endogenous Natural Product Research of Ethnopharmacological Plants (Project No. 21605164) (Principal Investigator).

  • Young and Middle-Aged Talent Program, National Ethnic Affairs Commission (Project No. 10301-0190040110) (Principal Investigator).

  • Research Achievement Transformation Project: A Non-Denaturing Protein Extraction Method and Its Specific Extraction Solution (Project No. JS2023001) (Principal Investigator).

  • Minzu University of China Youth Academic Team Leadership Project (Project No. 10301-02200301) (Principal Investigator).

  • Research Achievement Transformation Project: Transgenic Biosafety Assessment Based on Biological Imaging (Project No. 2022ZD04021) (Participant).

  • Independent Research Project, Minzu University of China: Study on New Methods for Mass Spectrometry Analysis and Imaging and Their Applications in Exploring the Material Basis of Traditional Chinese Medicine (Project No. 2019QNPY66) (Participant).

  • Minzu University of China Young Faculty Research Capability Development Project (Project No. 2017QNPY38) (Participant).

  • Independent Research Project, Minzu University of China: Exploring the Correlation between Multi-Omics Analysis and Eye Disease Mechanisms in Multi-Ethnic Groups (Project No. 2017MDYI27) (Participant).

  • Independent Research Project, Minzu University of China: Development of Probe-Assisted Laser Desorption Ionization Mass Spectrometry Methods and Their Applications in Metabolomics (Project No. 2016KYQN39) (Participant).

  • Genome Canada-Funded Project: Metabolomics and Technology Development, The Metabolomics Innovation Centre (TMIC) (April 2013 – March 2015) (Participant).

  • Genome Canada-Funded Project: Metabolomics and Technology Development, The Metabolomics Innovation Centre (TMIC) (April 2011 – March 2013) (Participant).

  • Genome Canada and Genome British Columbia Project: Proteomics Platform Funding from the Science and Technology Innovation Centre (S&TIC) (Participant).

  • General Program, National Natural Science Foundation of China: Study on the Structures of Tumor-Associated Protein Complexes in Plasma/Serum Using Mass Spectrometry (Project No. 21075137) (Participant).

  • Special Fund Project, National Natural Science Foundation of China: Abnormal Glycosylation of Proteins Related to Differentiated Thyroid Cancer and Early Serological Diagnosis (Project No. 81141031) (Participant).

  • General Program, National Natural Science Foundation of China: Proteomics Study on the Mechanism of Oncolytic Herpes Simplex Virus Enhancing Radiation Sensitivity of Pancreatic Cancer (Project No. 81071898) (Participant).

  • Special Fund Project, National Natural Science Foundation of China: Serum Marker Screening and Clinical Validation for Differentiated Thyroid Cancer Using Serum-Free Culture (Project No. 30940082) (Participant).

  • General Program, National Natural Science Foundation of China: Study on Proteasome Complexes Associated with Pancreatic Cancer Using Mass Spectrometry (Project No. 20675088) (Participant).

  • Doctoral Program Foundation of Higher Education Institutions: Development of New Techniques and Methods for the Study of Macromolecular Assembly Structures (Project No. 20070023023) (Participant).

  • National High Technology Research and Development Program (863 Program): Development of Screening Techniques for Novel Proteins Involved in the Ubiquitin-Proteasome Degradation Pathway in Tumor Cells (Project No. 2006AA02Z154) (Participant).

Representative Journal Papers
(*Corresponding Author, 31 papers published in CAS Q1 Journals, including 9 cover articles since 2021, 4 papers in Science China)

  1. Hao Hu, Kaidi Qiu, Qichen Hao, et al., Xiaodong Wang*. Electromagnetic Field-Assisted Frozen Tissue Planarization Enhances MALDI-MSI in Plant Spatial Omics. Analytical Chemistry, 2024, 96(29): 11809-11822. Cover Feature. (Top Journal, IF: 8.0, Q1, Nature-indexed)

  2. Lei Wang, Lamei Zheng, Hao Hu, et al., Xiaodong Wang*. MALDI Imaging Unveils Spatial Lipidomics Dynamics During Jojoba Seed Germination and Post-Germination. Industrial Crops and Products, 2024, 220: 119306. (Top Journal, IF: 6.5, Q1)

  3. Lulu Chen, Yue Zhang, Qichen Hao, et al., Xiaodong Wang*. Enhancement of In Situ Detection and Imaging of Phytohormones in Plant Tissues by MALDI-MSI Using 2,4-Dihydroxy-5-Nitrobenzoic Acid as a Novel Matrix. New Phytologist, 2024, 243(5): 2021-2036. (Top Journal, IF: 10.3, Q1)

  4. Lulu Chen, Yue Zhang, Yufen Bu, et al., Xiaodong Wang*. Imaging the Spatial Distribution of Structurally Diverse Plant Hormones: A Comprehensive Review. Journal of Experimental Botany, 2024, Accepted. (Top Journal, IF: 7.3, Q1)

  5. Zhentao Ren, Xin Yin, Laipan Liu, et al., Xiaodong Wang*. Flavonoid Localization in Soybean Seeds: Comparative Analysis of Wild (Glycine soja) and Cultivated (Glycine max) Varieties. Food Chemistry, 2024, 456(10): 139883. (Top Journal, IF: 9.2, Q1)

  6. Ran Wu, Dongxu Jiang, Hao Hu, et al., Xiaodong Wang*. 4-Aminoazobenzene: A Novel Negative Ion Matrix for Enhanced MALDI Tissue Imaging of Metabolites. Chinese Chemical Letters, 2024, 35(11): 109624. (Top Journal, IF: 9.1, Q1)

  7. Zhibin Bao, Dian Yu, Jinxiang Fu, et al., Xiaodong Wang*. 2-Hydroxy-5-Nitro-3-(Trifluoromethyl)Pyridine as a Novel Matrix for Enhanced MALDI Imaging of Tissue Metabolites. Analytical Chemistry, 2024, 96(13): 5160-5169. Cover Feature. (Top Journal, IF: 8.0, Q1, Nature-indexed)

  8. Hualei Xu, Manman Han, Haiqiang Liu, et al., Xiaodong Wang*. 4-Nitrocatechol as a Novel Matrix for Low-Molecular-Weight Compounds In Situ Detection and Imaging in Biological Tissues by MALDI-MSI. Chinese Chemical Letters, 2024, 35(6): 109095. (Top Journal, IF: 9.1, Q1)

  9. Qichen Hao, Liang Qin, Lulu Chen, et al., Xiaodong Wang*. Recent Advances in Gel Electrophoresis for the Study of Protein Complexes. SCIENTIA SINICA Vitae (Science China: Life Sciences), 2024, 54(5): 883-910.

  10. Yang Yu, Yong Zhou, Ivan A. Janssens, et al., Xiaodong Wang*. Divergent Rhizosphere and Non-Rhizosphere Soil Microbial Structure and Function in Long-Term Warmed Steppe Due to Altered Root Exudation. Global Change Biology, 2024, 30(1): e17111. (Top Journal, IF: 13.2, Q1)

  11. Hangjun Huang, Haiqiang Liu, Weiwei Ma, et al., Xiaodong Wang*. High-Throughput MALDI-MSI Metabolite Analysis of Plant Tissue Microarrays. Plant Biotechnology Journal, 2023, 21(12): 2574-2584. (Top Journal, IF: 14, Q1)

  12. Xin Yin, Zhentao Ren, Ruizong Jia, et al., Xiaodong Wang. Metabolic Profiling and Spatial Metabolite Distribution in Wild Soybean (G. soja) and Cultivated Soybean (G. max) Seeds. Food Chemistry: X, 2024, 23(4): 101717. (Top Journal, IF: 6.5, Q1)

  13. Jinxiang Fu, Jianchi Gu, Zhibin Bao, et al., Xiaodong Wang*. 2,5-Dihydroxyterephthalic Acid: A Matrix for Improved Detection and Imaging of Amino Acids. Analytical Chemistry, 2023, 95(51): 18709-18718. Cover Feature. (Top Journal, IF: 8.0, Q1, Nature-indexed)

  14. Lulu Chen, Liang Qin, Yawen Zhang, et al., Xiaodong Wang*. Insights from Multi-Omics Integration into Seed Germination of Taxus Chinensis var. mairei. Communications Biology, 2023, 6: 931. (Top Journal, IF: 6.6, Q1)

  15. Xiaodong Wang, Jun Han, Zhili Li, et al.* Editorial: Insight into Plant Spatial Omics: Mass Spectrometry Imaging. Frontiers in Plant Science, 2023. (Top Journal, IF: 6.6, Q2)

  16. Zhentao Ren, Liang Qin, Lulu Chen, et al., Xiaodong Wang*. Spatial Lipidomics of EPSPS and PAT Transgenic and Non-Transgenic Soybean Seeds Using MALDI-MSI. Journal of Agricultural and Food Chemistry, 2023, 71(26): 10190-10202. Cover Feature. (Top Journal, IF: 5.9, Q1)

  17. Yue Yin, Zhentao Ren, Li Zhang, et al., Xiaodong Wang*. In Situ Proteomic Analysis of Herbicide-Resistant Soybean and Hybrid Seeds via MALDI-MSI. Journal of Agricultural and Food Chemistry, 2023, 71(18): 7140-7151. (Top Journal, IF: 5.9, Q1)

  18. Chenyu Yang, Ran Wu, Haiqiang Liu, et al., Xiaodong Wang*. Polyacrylamide Gel as a New Embedding Medium for the Enhancement of Metabolite MALDI Imaging. Chemical Communications, 2023, 59(26): 3842-3845. Cover Feature. (Top Journal, IF: 6.8, Q1, Nature-indexed)

  19. Haiqiang Liu, Manman Han, Jinming Li, et al., Xiaodong Wang*. A Caffeic Acid Matrix Improves In Situ Detection and Imaging of Proteins with High Molecular Weight (~200 kDa) in Tissues by MALDI-MSI. Analytical Chemistry, 2021, 93(35): 11920-11928. Cover Feature. (Top Journal, IF: 8.0, Q1, Nature-indexed)

  20. Yiyang Shi, Hao Hu, Qichen Hao, et al., Xiaodong Wang*. Michler's Ethylketone as a Novel Negative-Ion Matrix for the Enhancement of Lipid MALDI Tissue Imaging. Chemical Communications, 2022, 58(5): 633-636. Cover Feature. (Top Journal, IF: 6.8, Q1, Nature-indexed)

  21. Ran Wu, Liang Qin, Lulu Chen, et al., Xiaodong Wang*. Copper Adhesive Tape Attached to the Reverse Side of Non-Conductive Glass Slide to Achieve Protein MALDI-Imaging in FFPE-Tissue Sections. Chemical Communications, 2021, 57(82): 10707-10710. Cover Feature. (Top Journal, IF: 6.8, Q1, Nature-indexed)

  22. Huixin He, Liang Qin, Yawen Zhang, et al., Xiaodong Wang*. 3,4-Dimethoxycinnamic Acid as a Novel Matrix for Enhanced In Situ Detection and Imaging of Low-Molecular-Weight Compounds in Biological Tissues by MALDI-MSI. Analytical Chemistry, 2019, 91(4): 2634-2643. (Top Journal, IF: 8.0, Q1, Nature-indexed)

  23. Yaqin Liu, Lulu Chen, Liang Qin, et al., Xiaodong Wang*. Enhanced In Situ Detection and Imaging of Lipids in Biological Tissues Using 2,3-Dicyanohydroquinone as a Novel Matrix for Positive-Ion MALDI-MS Imaging. Chemical Communications, 2019, 55(83): 12559-12562. (Top Journal, IF: 6.8, Q1, Nature-indexed)

  24. Xiaodong Wang, Jun Han, Juncong Yang, et al. Matrix Coating Assisted by an Electric Field (MCAEF) for Enhanced Tissue Imaging by MALDI-MS. Chemical Science, 2015, 6: 729-738. (Top Journal, IF: 10.0, Q1, Nature-indexed)

  25. Xiaodong Wang, Jun Han, Jingxi Pan, et al. Comprehensive Imaging of Porcine Adrenal Gland Lipids by MALDI-FTMS Using Quercetin as a Matrix. Analytical Chemistry, 2014, 86: 638-646. Highlighted in a Virtual Issue on Lipidomics-Analytical Chemistry. Cover Feature. (Top Journal, IF: 8.0, Q1, Nature-indexed)

  26. Xiaodong Wang, Jun Han, Albert Chou, et al. Hydroxyflavones as a New Family of Matrices for MALDI Tissue Imaging. Analytical Chemistry, 2013, 85: 7566-7573. (Top Journal, IF: 8.0, Q1, Nature-indexed)

  27. Xiaodong Wang, Fenjie Li, Gaoguang Song, et al. Broad-Spectrum Four-Dimensional Orthogonal Electrophoresis: A Novel Comprehensively Feasible System for Protein Complexomics Investigation. Molecular & Cellular Proteomics, 2012, 11: 786-799. (Top Journal, IF: 9.9, Q1)

  28. Jiao Wu, Chuang Cui, Hongwei Zhao, et al., Xiaodong Wang*. In-Situ Detection and Imaging of Areca catechu Fruit Alkaloids by MALDI-MSI. Industrial Crops and Products, 2022, 188: 115533. (Top Journal, IF: 6.4, Q1)

  29. Jinrong Li, Liang Qin, Dongxu Jiang, et al., Xiaodong Wang*. Chemical Derivatization: Recent Advances in Mass Spectrometry Imaging. SCIENTIA SINICA Chimica (Science China: Chemistry), 2022, 52(7): 1041-1073.

  30. Shuhang He, Lulu Chen, Liang Qin, et al., Xiaodong Wang*. Proteomics: Recent Advances in the Analysis of Diabetic Kidney Disease. SCIENTIA SINICA Vitae (Science China: Life Sciences), 2021, 54(4): 384-411.

  31. Yanliang Zhang, Liang Qin, Jingkuan Sun, et al., Xiaodong Wang*. Metabolite Changes Associated with Earthworms (Eisenia fetida) Graphene Exposure Revealed by MALDI-MSI. Ecotoxicology and Environmental Safety, 2020, 205: 111102. (Top Journal, IF: 7.1, Q1)

  32. Huixin He, Lulu Chen, Liang Qin, et al., Xiaodong Wang*. Mass Spectrometry Imaging for In Situ Analysis of Endogenous Molecules in Plants. SCIENTIA SINICA Vitae (Science China: Life Sciences), 2017, 47(10): 1043-1064.

  33. Hualei Xu, Qichen Hao, Haiqiang Liu, et al., Xiaodong Wang*. A Concentration-Descending Washing Strategy with Methanol for the Enhancement of Protein Imaging in Biological Tissues by MALDI-MS. Analyst, 2023, 148(4): 823-831. (IF: 5.2, Q2)

  34. Jialin Du, Weiwei Ma, Yi Li, et al., Xiaodong Wang*. UPLC-MS-Based Non-Targeted Analysis of Endogenous Metabolite Changes in the Leaves of Scabiosa tschiliensis Gruning Induced by 6-Benzylaminopurine and Kinetin. Frontiers in Plant Science, 2021, 12: 700623. (Top Journal, IF: 6.6, Q2)

  35. Yawen Zhang, Liang Qin, Lulu Chen, et al., Xiaodong Wang*. MALDI-MSI Analysis of Endogenous Lipid Changes in Zebrafish Exposures to Water Eutrophication. Science Technology and Engineering, 2021, 21(14): 5658-5667.

  36. Ming Lin, Jiamin Xu, Zhimin Liu, et al., Xiaodong Wang*. Complement Factor H Displays Opposite Expression Patterns Under Two Situations of Methamphetamine Administration: Acute Exposure and Chronic Dependence. Neuroscience Bulletin, 2020, 36: 1558-1562. (IF: 5.3, Q2)

  37. Liang Qin, Yawen Zhang, Yaqin Liu, et al., Xiaodong Wang*. Recent Advances in MALDI-MSI for In Situ Analysis of Endogenous Molecules in Plants. Phytochemical Analysis, 2018, 29(4): 351-364. (Invited Paper, IF: 3.4, Q2)

  38. Xiaodong Wang, Yujie Liu, Fenjie Li, et al. Poplar Catkin: A Natural Biomaterial for Highly Specific and Efficient Enrichment of Sialoglycopeptides. Chinese Chemical Letters, 2017, 28: 1018-1026. (Top Journal, IF: 9.1, Q1)

  39. Xiaodong Wang, Jun Han, Darryl B. Hardie, et al. Metabolomic Profiling of Prostate Cancer by MALDI-FTICR-MSI Using Matrix Coating Assisted by an Electric Field (MCAEF). Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2017, 1865: 755-767. (Invited Paper, IF: 4.1, Q3)

  40. Han Hang, Ma Yanfang, Li Zhengzhen, et al., Xiaodong Wang*. A Novel Method for Nondenaturing Protein Extraction from Populus euphratica Leaves. Science Technology and Engineering, 2018, 18(21): 36-41.

  41. Xiaodong Wang*, Bingshu He, Huixin He, and Liang Qin. Application of Metabolomics in the Study of Diabetic Nephropathy. Journal of Minzu University of China, 2017, 26: 58-64.

  42. Xiaodong Wang, Jun Han, Darryl B. Hardie, et al., Christoph H. Borchers*. The Use of Matrix Coating Assisted by an Electric Field (MCAEF) to Enhance Mass Spectrometric Imaging of Human Prostate Cancer Biomarkers. Journal of Mass Spectrometry, 2016, 51: 86-95. (Invited Paper, IF: 3.2, Q3)

  43. Xiaodong Wang, Guoqiang Chen, Hui Liu, et al., Zhili Li*. Four-Dimensional Orthogonal Electrophoresis System for Screening Protein Complexes and Protein-Protein Interactions Combined with Mass Spectrometry. Journal of Proteome Research, 2010, 9: 5325-5334. (IF: 5.4, Q2)

  44. Xiaodong Wang and Zhili Li*. Chemical Cross-Linking and Mass Spectrometry for Investigation of Protein Complex Structure and Protein-Protein Interactions. ACTA Biophysica Sinica, 2009, 25: 157-167. (2009 Excellent Paper)

  45. Wenqian Xie, Shengheng Mu, Jinkun Zhong, et al., Xiaodong Wang, Qiang Weng*. Mass Spectrometry Imaging of Lipids in the Scent Glands of Muskrat (Ondatra zibethicus) in Different Reproductive Statuses. Cells, 2022, 11(14): 2228. (IF: 7.7, Q2)

  46. Zhaopeng Geng, Na Hao, Jialin Du, et al., Xiaodong Wang, Junli Wang*. Micropropagation System of Anaphalis hancockii Maxim In Vitro and Exploration of Endogenous Metabolome Differences Caused by Plant Growth Regulators. Plant Cell, Tissue and Organ Culture (PCTOC), 2022. (IF: 2.7, Q3)

  47. Xiaohong Qi, Lulu Chen, Zijian Hu, et al., Xiaodong Wang, Bolin Zhang*, Jinxing Lin*. Cytology, Transcriptomics, and Mass Spectrometry Imaging Reveal Changes in Late-Maturation Elm (Ulmus pumila) Seeds. Journal of Plant Physiology, 2022, 271: 153639. (IF: 3.7, Q2)

  48. Chunyan Lan, Hainan Li, Lei Wang, et al., Xiaodong Wang, Ming Lu*, Xu Ma*. Absolute Quantification of 2-Hydroxyglutarate on Tissue by MALDI-MSI for Rapid and Precise Identification of Isocitrate Dehydrogenase Mutations in Human Glioma. International Journal of Cancer, 2021, 149(12): 2091-2098. (Top Journal, IF: 7.3, Q1)

  49. Jian Song, Shuyu Lai, Dingnan Wang, et al., Xiaodong Wang. Simultaneous Colorimetric Sensing of Malachite & Leucomalachite Green in Aquatic Products Based on Novel Ionic Associate Self-Visualization HPTLC Strips. Sensors and Actuators B: Chemical, 2020, 325: 128753. (Top Journal, IF: 9.2, Q1)

  50. Hanzhi Xiao, Wenshu Wang, Yusong Sun, et al., Xiaodong Wang, Feixian Luo*. Pd/Cu-Catalyzed Cascade C(sp3)-H Arylation and Intramolecular C-N Coupling: A One-Pot Synthesis of 3,4-2H-Quinolinone Skeletons. Organic Letters, 2019, 21(6): 1668-1671. (Top Journal, IF: 6.73, Q1, Nature-indexed)

  51. Qi Yang, Shibiao Liu, Xiaoning Han, et al., Xiaodong Wang*, Xinli Xia*. Integrated Transcriptome and miRNA Analysis Uncovers Molecular Regulators of Aerial Stem-to-Rhizome Transition in the Medical Herb Gynostemma pentaphyllum. BMC Genomics, 2019, 20(1): 865. (IF: 4.6, Q3)

  52. Teesha C. Luehr, Emily M. Koide, Xiaodong Wang, et al., Caren C. Helbing. Metabolomic Insights into the Effects of Thyroid Hormone on Rana [Lithobates] catesbeiana Metamorphosis Using MALDI-MSI. General and Comparative Endocrinology, 2018, 265: 237-245. (Invited Paper, IF: 3.3, Q3)

  53. Yanying Wang, Gaoguang Song, Yanmin Wang, et al., Xiaodong Wang, Zhili Li*. Elevated Serum Levels of Circulating Immunoinflammation-Related Protein Complexes Are Associated with Cancer. Journal of Proteome Research, 2014, 13: 710–719. (IF: 5.4, Q2)

  54. Fenjie Li, Xiaodong Wang, Yujie Liu, et al., Zhili Li*. Dephosphorylation of Intact Glycoprotein to Greatly Improve Digestion Efficiency Coupled with MALDI-FTICR-MS Analysis. Analytica Chimica Acta, 2013, 787: 140-147. (Top Journal, IF: 6.9, Q2)

  55. Guoqiang Chen, Yanmin Wang, Xuzhen Qin, et al., Xiaodong Wang, Zhili Li*. Change in IgG1 Fc N-Linked Glycosylation in Human Lung Cancer: Age- and Sex-Related Diagnostic Potential. Electrophoresis, 2013, 34: 2407-2416. (IF: 3.6, Q3)

  56. Fang Li, Xuzhen Qin, Haiquan Chen, et al., Xiaodong Wang, Zhili Li*. Lipid Profiling for Early Diagnosis and Progression of Colorectal Cancer Using Direct-Infusion ESI-FTICR-MS. Rapid Communications in Mass Spectrometry, 2013, 27: 24-34. (IF: 2.6, Q3)

  57. Guoqiang Chen, Yanmin Wang, Ling Qiu, et al., Xiaodong Wang, Zhili Li*. Human IgG Fc-Glycosylation Profiling Reveals Associations with Age, Sex, Female Sex Hormones, and Thyroid Cancer. Journal of Proteomics, 2012, 75: 2824-2834. (IF: 4.1, Q2)

  58. Yumei Guo, Xianmin Wang, Ling Qiu, et al., Xiaodong Wang, Zhili Li*. Probing Gender-Specific Lipid Metabolites and Diagnostic Biomarkers for Lung Cancer Using FTICR-MS. Clinica Chimica Acta, 2012, 414: 135-141. (IF: 6.3, Q3)

  59. Zhiyun Zhao, Hui Liu, Xinli Wang, et al., Xiaodong Wang, Zhili Li*. Separation and Identification of HSP-Associated Protein Complexes from Pancreatic Cancer Cell Lines Using 2D CN/SDS-PAGE Coupled with Mass Spectrometry. Journal of Biomedicine and Biotechnology, 2011, DOI: 10.1155/2011/193052. (IF: 3.2)

  60. Xinli Wang, Guoqiang Chen, Zhiyun Zhao, et al., Xiaodong Wang, Zhili Li*. Proteomics-Based Characterization of Protein Complexes from Human Pancreatic Cancer Cell Line. Chinese Journal of Chemistry, 2011, 29: 1548-1550. (IF: 6.0, Q2)

  61. Guoqiang Chen, Hui Liu, Xiaodong Wang, and Zhili Li*. In Vitro Methylation by Methanol: Proteomic Screening and Prevalence Investigation. Analytica Chimica Acta, 2010, 661: 67-75. (Top Journal, IF: 6.9, Q2)

Representative Publications
(Editor-in-Chief)

  1. Xiaodong Wang*, Liangyu Liu, Jun Han, Zhili Li, Bin Li, Yinglang Wan. Insight into Plant Spatial Omics: Mass Spectrometry Imaging. Frontiers Press, 2023, pp. 1–114, ISBN: 978-2-8325-3403-8.

Representative Conference Presentations

  1. Hosted the conference "China Agricultural Science Frontier Campus Tour – Structural Biology Frontier Technology Report" with the theme "Micro Conformation, Macro Exploration – Advances in Structural Biology." Beijing, April 7, 2024 (Conference Host).

  2. Xiaodong Wang. Insights from Multi-Omics Integration into Seed Germination of Taxus chinensis var. mairei. The 1st National Plant Integrative Omics Symposium, Guangxi, Nanning, April 12–15, 2024 (Convener of Multi-Omics Technology Sub-Session, Host, Oral Presentation).

  3. Xiaodong Wang. Mass Spectrometry Imaging of Endogenous Molecules in Plant Tissues. Plant Genomics and New Green Revolution – Young Scientists Forum, Beijing, June 19, 2024 (Oral Presentation).

  4. Xiaodong Wang. Four-Dimensional Orthogonal Gel Electrophoresis and Mass Spectrometry Imaging. CAS Youth Academic Exchange Meeting, Beijing, September 8, 2023 (Oral Presentation).

  5. Xiaodong Wang. Plant Spatial Omics Based on Mass Spectrometry Imaging. The 8th China Plant Protein Research Conference, Guizhou, Guiyang, July 28–31, 2023 (Oral Presentation).

  6. Xiaodong Wang. Seed Spatial Omics: Insights from Mass Spectrometry Imaging. The 8th National Seed Science and Technology Symposium, Yunnan, Lijiang, May 26–29, 2023 (Oral Presentation).

  7. Xiaodong Wang. Spatial Omics Research Based on Mass Spectrometry Imaging. Clinical Mass Spectrometry Application Seminar, Beijing, September 1, 2022 (Oral Presentation).

  8. Xiaodong Wang. Novel MALDI-MSI Technologies and Their Applications in Biological Sciences. Academic Salon, Institute of Basic Research, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, March 30, 2022 (Oral Presentation).

  9. Xiaodong Wang. Applications of MALDI Mass Spectrometry Imaging in Epidemiology. Chinese Center for Disease Control and Prevention Academic Exchange, Beijing, January 20, 2022 (Oral Presentation).

  10. Xiaodong Wang. Applications of MALDI Source Mass Spectrometry Imaging in Life Sciences. "Scientific Thinking and Research Methods in Laboratory Medicine" Symposium, Beijing, November 2, 2021 (Oral Presentation).

  11. Xiaodong Wang. Applications of Mass Spectrometry Imaging in Biological Sciences. 14th Academic Annual Meeting of the Chinese Society of Biotechnology, Summit on Supporting Life Science Technologies, Shanxi, Jinzhong, October 15–17, 2021 (Oral Presentation).

  12. Xiaodong Wang. Four-Dimensional Orthogonal Gel Electrophoresis Technology. Lecture at Capital Normal University, Beijing, October 27, 2020 (Oral Presentation).

  13. Xiaodong Wang. Applications of Mass Spectrometry in In Situ Characterization of Endogenous Molecules in Plants. Life Science Forum, Beijing Forestry University, Beijing, July 12, 2018 (Oral Presentation).

  14. Xiaodong Wang. Applications of Mass Spectrometry in Medicine. 6th Training Workshop on Clinical Applications of Mass Spectrometry (National Continuing Education Program, Tongren Hospital), Beijing, July 7, 2018 (Oral Presentation).

  15. Xiaodong Wang; Huixin He; Liang Qin; Yaqin Liu; Yawen Zhang; Manman Han, 3,4-dimethoxycinnamic acid (DMCA) as a novel matrix for the in situ analysis of small metabolites in biological samples by MALDI-TOF-MS. The 66th ASMS Conference on Mass Spectrometry and Allied Topics, 2018, San Diego Convention Center, San Diego, CA, 2018.06.03-06.07 (Poster presentation)

  16. Liang Qin, Huixin He, Yaqin Liu, Hang Han, Wanqian Feng, Yuting Lan, Xin Liu, Juan Zhang, Yanfang Ma, Tianze Li, and Xiaodong Wang*, MALDI mass spectrometry imaging as a novel molecular microscopy for in situ detection of high molecular weight proteins. The 17th Beijing Conference and Exhibition on Instrumental Analysis (BCEIA2017), 2017, China National Convention Center, Beijing, China, 2017. 10. 09 - 10. 11 (Poster presentation)

  17. Xiaodong Wang, Huixin He, Liang Qin, Lulu Chen, Yaqin Liu, Caffeic acid as a new matrix for enhanced tissue imaging of high molecular weight proteins by MALDI mass spectrometry. The 65th ASMS Conference on Mass Spectrometry and Allied Topics, 2017, Indiana Convention Center, Indianapolis, IN, USA, 2017. 06.04 - 06.08 (Poster presentation)

  18. Xiaodong Wang, Jun Han, Juncong Yang, Jingxi Pan, Christoph H. Borchers, Matrix Coating Assisted by an Electric Field (MCAEF)-LDI Imaging of Prostate Cancer Tissue Biomarkers. The 14th Human Proteome Organization World Congress (HUPO 2015), 2015, Vancouver Convention Centre, Vancouver, Canada, 2015.09.27 - 09.30 (Poster presentation)

  19. Xiaodong Wang, Jun Han, Juncong Yang, Jingxi Pan, Christoph H. Borchers, Imaging of prostate cancer tissue biomarkers by MCAEF (matrix coating assisted by an electric field) - laser desorption/ionization mass spectrometry. The 11th Annual International Conference of the Metabolomics Society – Metabolomics, 2015, Hyatt Regency Burlingame, San Francisco, California, USA, 2015. 06. 29 - 07. 02 (Poster presentation)

  20. Xiaodong Wang, Jun Han, Juncong Yang, Jingxi Pan, Christoph H. Borchers, MCAEF (Matrix coating assisted by an electric field): a novel technique for enhanced imaging of biomarker candidates for prostate cancer. The 63th ASMS Conference on Mass Spectrometry and Allied Topics, 2015, America's Center, St. Louis, Missouri, USA, 2015. 05. 31 - 06. 04 (Poster presentation)

  21. Xiaodong Wang, Jun Han, Juncong Yang, Jingxi Pan, Christoph H. Borchers, Quercetin as a highly efficient MALDI matrix for negative-ion tissue imaging by FTICR-MS. The 62th ASMS Conference on Mass Spectrometry and Allied Topics, 2014, Baltimore Convention Center, Baltimore, MD, USA, 2014. 06. 15 – 06. 19 (Poster presentation)

  22. Xiaodong Wang, Jun Han, Juncong Yang, Jingxi Pan, Christoph H. Borchers, Profiling and imaging of lipids on rat brain and human prostate cancer tissues by negative-ion FTICR-MS using quercetin as a MALDI matrix. The 97th Canadian Chemistry Conference and Exhibition, 2014, Hyatt Regency Vancouver, Vancouver, British Columbia, Canada, 2014. 06. 01 - 06. 05 (Poster presentation)

  23. Xiaodong Wang, Jun Han, Juncong Yang, Jingxi Pan, Christoph H. Borchers, Enhancement of lipid sensitivity by negative-ion FTICR-MS using quercetin as a MALDI matrix. The 6th Annual CNPN Symposium: "Proteome Dynamics in Health and Diseases", 2014, Hilton Bonaventure, Montreal, Quebec, Canada, 2014. 04. 14 - 04. 16 (Oral presentation)

  24. Xiaodong Wang, Jun Han, Juncong Yang, Jingxi Pan, Christoph H. Borchers, Enhancement of lipid imaging by negative-ion FTICR-MS using quercetin as a MALDI matrix. The 6th Annual CNPN Symposium: "Proteome Dynamics in Health and Diseases", 2014, Hilton Bonaventure, Montreal, Quebec, Canada, 2014. 04. 14 - 04. 16 (Poster presentation)

  25. Xiaodong Wang, Jun Han, Albert Chou, Juncong Yang, Jingxi Pan, Christoph H. Borchers, Hydroxyflavones as a new family of matrices for MALDI tissue imaging. The 61th ASMS Conference on Mass Spectrometry and Allied Topics, 2013, Minneapolis Convention Center, Minneapolis, MN, USA, 2013. 06. 08 - 06. 12 (Poster presentation)

  26. Xiaodong Wang, Jun Han, Albert Chou, Juncong Yang, Jingxi Pan, Christoph H. Borchers, Polyhydroxyflavones as a new family of matrices for MALDI tissue imaging. The 5th Annual CNPN Symposium:"Can Proteomics Fill the Gap Between Genomics and Phenotypes?" 2013, Coast Coal Harbour Hotel, Vancouver, British Columbia, Canada, 2013. 04. 20 - 04. 24 (Poster presentation)

  27. Xiaodong Wang, Fenjie Li, Gaoguang Song, Shuai Guo, Hui Liu, Guoqiang Chen, Zhili Li, A novel comprehensively feasible system profiling of protein complexomics. The 17th International Biophysics Congress (IUPAB), 2011, China National Convention Center, Beijing, China, 2011. 10. 30 - 11. 03 (Poster presentation)

  28. Xiaodong Wang, Gaoguang Song, Fenjie Li, Shuai Guo, Hui Liu, Guoqiang Chen, Zhili Li, Multi-dimensional orthogonal electrophoresis system for screening protein complexes and protein-protein interactions combined with mass spectrometry. The 3rd Conference and Seminar of the National Analytical Chemistry for life Science, 2010, Peking University, Beijing, China, 2011. 08. 19 - 08.22 (Poster presentation)

  29. Xiaodong Wang, Gaoguang Song, Yanying Wang, Zhiyun Zhao, Hui Liu, Guoqiang Chen, Zhili Li, Novel 2-DE combined with MALDI-FTICR MS for differential proteins investigation between the serum of normal and leukemia. National Conference of Mass Spectrometry & the 3rd Conference of world Chinese on Mass Spectrometry, 2010, Changchun Institute of Applied Chemistry, Changchun, China, 2010. 07. 30 - 08. 01 (Poster presentation)

  30. Xiaodong Wang, Zhili Li, Multi-dimensional orthogonal electrophoresis system (4-DE) for investigation of protein complexes combined with mass spectrometry. The 58th ASMS Conference on Mass Spectrometry and Allied Topics, 2010, Salt Palace Convention Center, Salt Lake City, Utah, USA, 2010. 05. 23 - 05. 27 (Poster presentation)

  31. Christoph H. Borchers, Xiaodong Wang, Jun Han, Multiplexed Imaging of Biomolecules in Tissues by MALDI-MS. The 14th Human Proteome Organization World Congress (HUPO 2015), 2015, Vancouver Convention Centre, Vancouver, Canada, 2015.09.27 - 09.30 (Oral presentation)

  32. Christoph H. Borchers, Xiaodong Wang, Jun Han, Multiplexed imaging of biomolecules in tissues by matrix-assisted laser desorption/ionization mass spectrometry. The 11th Annual International Conference of the Metabolomics Society – Metabolomics, 2015, Hyatt Regency Burlingame, San Francisco, California, USA. 2015. 06. 29 - 07. 02 (Poster presentation)

  33. Zhiyun Zhao, Xiaodong Wang, Guoqiang Chen, Zhili Li, Two-dimensional Native/SDS PAGE analysis reveals different protein complexes from two pancreatic cell lines. The 13rd Beijing Conference and Exhibition on Instrumental Analysis, 2009, Central Garden Hotel, Beijing, China, 2009. 10. 13 - 10. 16 (Poster presentation)

Patents (Granted or Applied)

International Patents:

  1. System and Method for Matrix-Coating Samples for Mass Spectrometry. Patent No.: WO2015/196303A1

United States Patents:

  1. System and Method for Matrix-Coating Samples for Mass Spectrometry. Patent No.: US 20170148618A1

Domestic Patents:

  1. A Method for Enriching Sialylated Glycopeptides. Patent No.: ZL 2014 1 0035250.9

  2. A Non-Denaturing Protein Extraction Method and Its Specialized Extraction Solution. Patent No.: ZL 2018 1 0128474.2 (Successfully Commercialized).

  3. An Alternating Electric Field Coupled with High-Frequency Vibration-Assisted Matrix Spraying Method. Patent No.: ZL 2020 1 0792902.9

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