Xiaodong Wang
Ph.D. (Peking Union Medical College, Tsinghua University), Professor, Distinguished Research Fellow,Principal Investigator (Academic Leader) &Excellent Talent (2016) in Minzu University of China.
Research Scientist & Postdoctoral Fellow (University of Victoria - Genome BC Proteomics Centre, Canada, 2012-2015), Research Scientist (Metabolomics Innovation Centre (TMIC) &Science and Technology Innovation Centre (STIC), Canada, 2012-2015).
Members in Human Proteome Organization (HUPO), American Society for Mass Spectrometry (ASMS), American Chemical Society (ACS), Canadian National Proteomics Network (CNPN), and Canadian Society for Chemistry (CSC).
Invited as a Peer-reviewer for Molecular & Cellular Proteomics, Analytical Chemistry, Analytica Chimica Acta, Journal of Mass Spectrometry, Journal of Proteome Research, Proteomics, Journal of Proteomics, Electrophoresis, International Journal of Mass Spectrometry, Analytical and Bioanalytical Chemistry, Journal of the American Society for Mass Spectrometry, Rapid Communications in Mass Spectrometry, Metabolomics, Methods, RSC Advances, and Analyst.Invited as a Guest Editor for Analytical Methods in Chemistry.
· 2014_Young Investigator Award, awarded by Genome Canada in 6th Annual CNPN Symposium
· 2012_Beijing’s Outstanding Postgraduates Award (Certificate No: 201210023y014), awarded by Beijing Municipal Education Commission
· 2009_Outstanding Paper awarded by Journal of ACTA Biophysica sincia
· The First Class Postgraduate Scholarship Award, awarded by PUMC (2011, 2010)
· The Third Class Postgraduate Scholarship Award, awarded by PUMC (2008)
· Outstanding Postgraduate Student Award, awarded by PUMC (2011, 2010, 2009)
· The First Class Research Assistantship Award, awarded by PUMC (2010, 2009)
· The Second Class Research Assistantship Award, awarded by PUMC (2011)
· The First Class Undergraduate Innovation Scholarship Award, awarded by National Science Talent Training Base (2006)
Address:
Centre for Imaging & Systems Biology, College of Life and Environmental Sciences, Minzu University of China
# 27 Zhongguancun South St., Haidian District, Beijing, China, 100081
Email:Xiaodong@muc.edu.cn
Personal Homepage:https://www.researchgate.net/profile/Xiaodong_Wang21
Teaching
Ø For Undergraduates:Modern Instrumental Analysis, Instrumental Analysis Experiment, Proteomics, Introduction of Chemistry, Introduction of Pharmaceutical Engineering, Expert lecture series for Innovation Class
Ø For Postgraduates:Modern Instrumental Analysis, Introduce to OMICS
Research Interest
Research Emphasis: Mass Spectrometry, BioImaging, Analytical Chemistry, Proteomics & Metabolomics, Oncology, Medico-botany /Edible-botany
Research in my interest is mainly focusing on developing and implementing an array of mass spectrometry based novel analytical strategies to decipher puzzles about the most complex and elusive set of endo-/exo-genous molecules, such as proteins/protein complexes, neuropeptides, lipids, hormones, drugs, and so on, and obtain new insights into the physiological roles of these signaling molecules play in the progression of human diseases and/or plant stress tolerance. Although significant effort has been directed in recent years towards analytical technique and method development, it is the biomedical importance of understanding the mechanisms of disease progression and/or plant tolerance that drives my research to continuously develop and refine/improve the analytical capabilities to address challenging oncology and/or botany problems. A large body of research strongly shows that an imbalance or abnormal modification of chemical messengers in vivo is always associated with various disorders or diseases in both of human and plant. However, compared to classical signaling molecules such as peptides, the functional roles of many glycopeptides are still poorly understood, much less sialylated glycopeptides. This is, in part, due to the lack of analytical capabilities to measure and identify these low abundance endo-/exo-genous signaling molecules in a complex microenvironment. Obviously, development of highly sensitive and selective analytical methods or techniques for endo-/exo-genous molecules in vivo identification and quantitation is in great demand.
Selected Publications
1.Xiaodong Wang, Yujie Liu, Fenjie Li, and Zhili Li*. Poplar catkin: a natural biomaterial for highly specific and efficient enrichment of sialoglycopeptides.Chinese Chemical Letters, 2017, 28, 1018-1026. (IF: 2.0)
2.Xiaodong Wang, Jun Han, Darryl B. Hardie, Juncong Yang, Jingxi Pan, and Christoph H. Borchers*. Metabolomic profiling of prostate cancer by matrix assisted laser desorption/ionization-fourier transform ion cyclotron resonance mass spectrometry imaging using matrix coating assisted by an electric field (MCAEF).Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2017, 1865, 755-767. (Invited paper_IF: 3.7)
3.Xiaodong Wang, Jun Han, Darryl B. Harde, Juncong Yang, and Christoph H. Borchers*, The use of matrix coating assisted by an electric field (MCAEF) to enhance mass spectrometric imaging of human prostate cancer biomarkers,Journal of Mass Spectrometry, 2016, 51, 86-95. (Invited paper_IF: 2.5)
4.Xiaodong Wang, Jun Han, Juncong Yang, Jingxi Pan, and Christoph H. Borchers*. Matrix Coating Assisted by an Electric Field (MCAEF) for enhanced tissue imaging by MALDI-MS.Chemical Science,2015, 6, 729-738. (Top Journal_IF: 9.2)
5.Xiaodong Wang, Jun Han, Jingxi Pan, and Christoph H. Borchers*. Comprehensive imaging of porcine adrenal gland lipids by MALDI-FTMS using quercetin as a matrix.Analytical Chemistry,2014, 86, 638-646. Highlighted in a Virtual Issue on Lipidomics-Analytical Chemistry. Cover feature. (Top Journal_IF: 5.9)
6.Xiaodong Wang, Jun Han, Albert Chou, Juncong Yang, Jingxi Pan, and Christoph H. Borchers*. Hydroxyflavones as a new family of matrices for MALDI tissue imaging.Analytical Chemistry, 2013, 85, 7566-7573. (Top Journal_IF: 5.9)
7.Xiaodong Wang, Fenjie Li, Gaoguang Song, Shuai Guo, Hui Liu, Guoqiang Chen, and Zhili Li*. Broad-spectrum four-dimensional orthogonal electrophoresis: a novel comprehensively feasible system for protein complexomics investigation.Molecular & Cellular Proteomics,2012, 11, 786-799. (Top Journal_IF: 7.3)
8.Xiaodong Wang, Guoqiang Chen, Hui Liu, Zhiyun Zhao, and Zhili Li*. Four-dimensional orthogonal electrophoresis system for screening protein complexes and protein-protein interactions combined with mass spectrometry.Journal of Proteome Research,2010, 9, 5325-5334. (IF: 5.1)
9.Xiaodong Wangand Zhili Li*. Chemical cross-linking and mass spectrometry for investigation of protein complex structure and protein-protein interactions.ACTA Biophysica Sincia,2009, 25, 157-167. (2009_Excellent Paper)
10.Bingshu He, Huixin He, Liang Qin,Xiaodong Wang*. Application of metabolomics in the study of diabetic nephropathy.Journal of Minzu University of China, 2017, Accepted.
11.Huixin He, Lulu Chen, Liang Qin, Yaqin Liu, and Xiaodong Wang*. Mass spectrometry imaging and its application to in situ analysis of endogenous molecules in plants.SCIENTIA SINICA Vitae, 2017 (Revision submitted)
12.Huixin He, Liang Qin, Yaqin Liu, Hang Han, Yanyan Li, Zhonghua Wang, Yijun Zhou, Jinchao Feng, Jun Han, Carol E. Parker, Christoph H. Borchers,Zeper Abliz*, andXiaodong Wang*. Caffeic acid as a new matrix for enhanced tissue imaging of high molecular weight proteins by MALDI mass spectrometry. (Manuscript in preparation)
13.Yanying Wang, Gaoguang Song, Yanmin Wang, Ling Qiu, Xuzhen Qin, Hui Liu, Fang Li,Xiaodong Wang, Fenjie Li, Shuai Guo, Yaping Zhang, and Zhili Li*. Elevated serum levels of circulating immunoinflammation-related protein complexes are associated with cancer.Journal of Proteome Research,2014, 13, 710–719. (IF: 5.1)
14.Fenjie Li,Xiaodong Wang, Yujie Liu, Hui Liu, and Zhili Li*. Dephosphorylation of intact glycoprotein to greatly improve digestion efficiency coupled with matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometric analysis.Analytica Chimica Acta,2013, 787, 140-147. (IF: 4.7)
15.Guoqiang Chen, Yanmin Wang, Xuzhen Qin, Hexiang Li, Yumei Guo, Yanying Wang, Hui Liu,Xiaodong Wang, Gaoguang Song, Fang Li, Fenjie Li, Shuai Guo, Ling Qiu, and Zhili Li*. Change in IgG1 Fc N-linked glycosylation in human lung cancer: Age- and sex-related diagnostic potential.Electrophoresis,2013, 34, 2407-2416. (IF: 3.2)
16.Fang Li, Xuzhen Qin, Haiquan Chen, Ling Qiu, Yumei Guo, Hui Liu, Guoqiang Chen, Gaoguang Song,Xiaodong Wang, Fenjie Li, Shuai Guo, Baohua Wang, and Zhili Li*.Lipid profiling for early diagnosis and progression of colorectal cancer using direct-infusion electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.Rapid Communications in Mass Spectrometry,2013, 27, 24-34.(IF: 2.6)
17.Guoqiang Chen, Yanmin Wang, Ling Qiu, Xuzhen Qin, Hui Liu,Xiaodong Wang, Yanying Wang, Gaoguang Song, Fang Li, Yumei Guo, Fenjie Li, Shuai Guo, and Zhili Li*. Human IgG Fc-glycosylation profiling reveals associations with age, sex, female sex hormones and thyroid cancer.Journal of Proteomics,2012, 75, 2824-2834. (IF: 4.1)
18.Yumei Guo, Xianmin Wang, Ling Qiu, Xuzhen Qin, Hui Liu, Yanying Wang, Fang Li,Xiaodong Wang, Guoqiang Chen, Gaoguang Song, Fenjie Li, Shuai Guo, and Zhili Li*.Probing gender-specific lipid metabolites and diagnostic biomarkers for lung cancer using Fourier transform ion cyclotron resonance mass spectrometry.Clinica Chimica Acta,2012, 414, 135-141. (IF: 2.9)
19.Zhiyun Zhao, Hui Liu, Xinli Wang,Xiaodong Wang, and Zhili Li*. Separation and identification of HSP-associated protein complexes from pancreatic cancer cell lines using 2D CN/SDS-PAGE coupled with mass spectrometry.Journal of Biomedicine and Biotechnology,2011, DOI: 10.1155/2011/193052.(IF: 3.2)
20.Xinli Wang, Guoqiang Chen, Zhiyun Zhao,Xiaodong Wang, and Zhili Li*. Proteomics-based Characterization of Protein Complexes from Human Pancreatic Cancer Cell Line.Chinese Journal of Chemistry,2011, 29, 1548-1550.(IF: 1.9)
21.Guoqiang Chen, Hui Liu,Xiaodong Wang, and Zhili Li*.In vitromethylation by methanol: proteomic screening and prevalence investigation.Analytica Chimica Acta,2010, 661, 67-75.(IF: 4.7)
Selected conference Papers
1.Xiaodong Wang, Huixin He, Liang Qin, Lulu Chen, Yaqin Liu, Caffeic acid as a new matrix for enhanced tissue imaging of high molecular weight proteins by MALDI mass spectrometry.The 65th ASMS Conference on Mass Spectrometry and Allied Topics, 2017, Indiana Convention Center, Indianapolis, IN, USA, 2017. 06.04 - 06.08 (Poster presentation)
2.Xiaodong Wang, Jun Han, Juncong Yang, Jingxi Pan, Christoph H. Borchers, Matrix Coating Assisted by an Electric Field (MCAEF)-LDI Imaging of Prostate Cancer Tissue Biomarkers.The 14th Human Proteome Organization World Congress (HUPO 2015),2015,Vancouver Convention Centre, Vancouver, Canada, 2015.09.27 - 09.30(Poster presentation)
3.Xiaodong Wang, Jun Han, Juncong Yang, Jingxi Pan, Christoph H. Borchers, Imaging of prostate cancer tissue biomarkers by MCAEF (matrix coating assisted by an electric field) - laser desorption/ionization mass spectrometry.The 11th Annual International Conference of the Metabolomics Society –Metabolomics,2015, Hyatt Regency Burlingame, San Francisco, California, USA, 2015. 06. 29 - 07. 02 (Poster presentation)
4.Xiaodong Wang, Jun Han, Juncong Yang, Jingxi Pan, Christoph H. Borchers, MCAEF (Matrix coating assisted by an electric field): a novel technique for enhanced imaging of biomarker candidates for prostate cancer.The 63th ASMS Conference on Mass Spectrometry and Allied Topics, 2015, America's Center, St. Louis, Missouri, USA, 2015. 05. 31 - 06. 04 (Poster presentation)
5.Xiaodong Wang, Jun Han, Juncong Yang, Jingxi Pan, Christoph H. Borchers, Quercetin as a highly efficient MALDI matrix for negative-ion tissue imaging by FTICR-MS.The 62th ASMS Conference on Mass Spectrometry and Allied Topics, 2014, Baltimore Convention Center, Baltimore, MD, USA, 2014. 06. 15 – 06. 19 (Poster presentation)
6.Xiaodong Wang, Jun Han, Juncong Yang, Jingxi Pan, Christoph H. Borchers, Profiling and imaging of lipids on rat brain and human prostate cancer tissues by negative-ion FTICR-MS using quercetin as a MALDI matrix.The 97th Canadian Chemistry Conference and Exhibition, 2014, Hyatt Regency Vancouver, Vancouver, British Columbia, Canada, 2014. 06. 01 - 06. 05 (Poster presentation)
7.Xiaodong Wang, Jun Han, Juncong Yang, Jingxi Pan, Christoph H. Borchers, Enhancement of lipid sensitivity by negative-ion FTICR-MS using quercetin as a MALDI matrix.The 6th Annual CNPN Symposium:"Proteome Dynamics in Health and Diseases", 2014, Hilton Bonaventure, Montreal, Quebec, Canada, 2014. 04. 14 - 04. 16 (Oral presentation)
8.Xiaodong Wang, Jun Han, Juncong Yang, Jingxi Pan, Christoph H. Borchers, Enhancement of lipid imaging by negative-ion FTICR-MS using quercetin as a MALDI matrix.The 6th Annual CNPN Symposium:"Proteome Dynamics in Health and Diseases", 2014, Hilton Bonaventure, Montreal, Quebec, Canada, 2014. 04. 14 - 04. 16 (Poster presentation)
9.Xiaodong Wang, Jun Han, Albert Chou, Juncong Yang, Jingxi Pan, Christoph H. Borchers, Hydroxyflavones as a new family of matrices for MALDI tissue imaging.The 61th ASMS Conference on Mass Spectrometry and Allied Topics, 2013, Minneapolis Convention Center, Minneapolis, MN, USA, 2013. 06. 08 - 06. 12 (Poster presentation)
10.Xiaodong Wang, Jun Han, Albert Chou, Juncong Yang, Jingxi Pan, Christoph H. Borchers, Polyhydroxyflavones as a new family of matrices for MALDI tissue imaging.The 5th Annual CNPN Symposium:"Can Proteomics Fill the Gap Between Genomics and Phenotypes?"2013, Coast Coal Harbour Hotel, Vancouver, British Columbia, Canada, 2013. 04. 20 - 04. 24 (Poster presentation)
11.Xiaodong Wang, Fenjie Li, Gaoguang Song, Shuai Guo, Hui Liu, Guoqiang Chen, Zhili Li, A novel comprehensively feasible system profiling of protein complexomics.The 17th International Biophysics Congress (IUPAB),2011, China National Convention Center, Beijing, China, 2011. 10. 30 - 11. 03 (Poster presentation)
12.Xiaodong Wang, Gaoguang Song, Fenjie Li, Shuai Guo, Hui Liu, Guoqiang Chen, Zhili Li, Multi-dimensional orthogonal electrophoresis system for screening protein complexes and protein-protein interactions combined with mass spectrometry.The 3rd Conference and Seminar of the National Analytical Chemistry for life Science, 2010, Peking University, Beijing, China, 2011. 08. 19 - 08.22 (Poster presentation)
13.Xiaodong Wang, Gaoguang Song, Yanying Wang, Zhiyun Zhao, Hui Liu, Guoqiang Chen, Zhili Li, Novel 2-DE combined with MALDI-FTICR MS for differential proteins investigation between the serum of normal and leukemia.National Conference of Mass Spectrometry & the 3rd Conference of world Chinese on Mass Spectrometry, 2010, Changchun Institute of Applied Chemistry, Changchun, China, 2010. 07. 30 - 08. 01 (Poster presentation)
14.Xiaodong Wang, Zhili Li, Multi-dimensional orthogonal electrophoresis system (4-DE) for investigation of protein complexes combined with mass spectrometry.The 58th ASMS Conference on Mass Spectrometry and Allied Topics, 2010, Salt Palace Convention Center, Salt Lake City, Utah, USA, 2010. 05. 23 - 05. 27 (Poster presentation)
15.Christoph H. Borchers,Xiaodong Wang,Jun Han, Multiplexed Imaging of Biomolecules in Tissues by MALDI-MS.The 14th Human Proteome Organization World Congress (HUPO 2015),2015,Vancouver Convention Centre, Vancouver, Canada, 2015.09.27 - 09.30 (Oralpresentation)
16.Christoph H. Borchers,Xiaodong Wang, Jun Han, Multiplexed imaging of biomolecules in tissues by matrix-assisted laser desorption/ionization mass spectrometry.The 11th Annual International Conference of the Metabolomics Society –Metabolomics,2015, Hyatt Regency Burlingame, San Francisco, California, USA. 2015. 06. 29 - 07. 02 (Poster presentation)
17.Zhiyun Zhao,Xiaodong Wang, Guoqiang Chen, Zhili Li, Two-dimensional Native/SDS PAGE analysis reveals different protein complexes from two pancreatic cell lines.The 13rd Beijing Conference and Exhibition on Instrumental Analysis, 2009, Central Garden Hotel, Beijing, China, 2009. 10. 13 - 10. 16 (Poster presentation)
Patents
1.System and method for matrix-coating samples for mass spectrometry (International patent: WO2015/196303A1)
2.Method for enrichment of sialylated glycopeptides (ZL201410035250.9)
