Zhonghua WANG
Associate Professor, Master’s Supervisor,
Postal address: College of Life and Environmental Sciences, Minzu University of China, 27 Zhong guan cun South Avenue, Haidian district, Beijing 100081, P. R. China
E-mail:wangzhonghua@muc.edu.cn
Individual Homepage:https://www.researchgate.net/profile/Zhonghua_Wang12
Doctor of Science (Peking Union Medical College - Tsinghua University)
Visiting Scholar, University of Montreal, Canada
Beijing Outstanding Young Talent, Key Academic Secretary of the National Ethnic Affairs Commission’s Key Laboratory of Mass Spectrometry Imaging and Metabolomics
Academic Backbone of the “Mass Spectrometry Imaging and Metabolomics” High-Level Talent Program in Beijing. Awarded the Beijing Outstanding Graduate in 2015. For nearly 15 years, has been engaged in research related to mass spectrometry analysis. Has accumulated extensive experience in qualitative, quantitative, and localized analysis of small molecules (including drugs, natural products, and endogenous metabolites) in complex biological systems. Related findings have been published in prestigious journals such as Acta Pharmaceutica Sinica B, Journal of Pharmaceutical Analysis, and Journal of Proteome Research, with over 20 research papers and 2 authorized patents. Reviewer for over 10 international journals, including Talanta, Biomarker, Scientific Reports, Rapid Communications in Mass Spectrometry, and European Journal of Pharmaceutics and Biopharmaceutics.
Teaching
Principles and Applications of Mass Spectrometry Analysis
Introduction to Modern Chromatography
Organic Chemistry Laboratory, etc.
Organic chemistry
Research Interests
Primarily engaged in the development of molecular imaging and metabolomics analysis methods based on mass spectrometry technology, with applications in the study of the pathogenesis of diabetic complications, characterization of bioactive components of medicinal plants, and drug metabolism.
Representative papers
1. Yanhua Liu, Xin Zhang, Shu Yang, Zhi Zhou, Lu Tian, Wanfang Li, Jinfeng Wei, Zeper Abliz*, Zhonghua Wang*. Integrated mass spectrometry imaging reveals spatial-metabolic alteration in diabetic cardiomyopathy and the intervention effects of ferulic acid, Journal of Pharmaceutical Analysis, 2023, 8.17，DOI: 10.1016/j.jpha.2023.08.011 (IF: 8.8)
2. Xianyue Meng1, Yanhua Liu1, Meiling Huo, Shu Yang, Xin Zhang, Lu Tian, Wanfang Li, Jinfeng Wei, Zhaoying Wang, Zhi Zhou, Yanhua Chen, Zhonghua Wang*, Zeper Abliz. Mapping of fatty aldehydes in the diabetic rat brain using on-tissue chemical derivatization and air-flow-assisted desorption electrospray ionization-mass spectrometry imaging, Journal of Proteome Research, 2023, 22 (1), 36-46. (IF: 4.4)
3. Xin Zhang, Yanhua Liu, Shu Yang, Xin Gao, Shuo Wang, Zhaoying Wang, Chen Zhang, Zhi Zhou, Yanhua Chen, Zhonghua Wang*, Zeper Abliz. Comparison of local metabolic changes in diabetic rodent kidneys using mass spectrometry imaging, Metabolites 2023, 13, 324. (IF: 4.1)
4. Yanhua Liu, Yuxin Cai, Xueying Bai, Xinyu Zhao, Xianyue Meng, Xin Zhang, Zhaoying Wang, Zhi Zhou, Yanhua Chen, Zhonghua Wang*, Zeper Abliz. A sensitive on-tissue chemical derivatization-mass spectrometry imaging method for the quantitative visualization of helicid in mice. International Journal of Mass Spectrometry, 2023, 488: 117038. (IF:1.8)
5. Zhonghua Wang1, Wenqing Fu1, Meiling Huo, Bingshu He, Yaqi Liu, Lu Tian, Wanfang Li, Zhi Zhou, Baili Wang, Jianzhen Xia, Yanhua Chen, Jinfeng Wei, Zeper Abliz*. Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging. Acta Pharmaceutica Sinica B. 2021, 11(11):3665-3677. (IF: 14.9)
6. Meiling Huo, Zhonghua Wang*, Wenqing Fu, Lu Tian, Wanfang Li, ZhiZhou, Yanhua Chen, Jinfeng Wei, Zeper Abliz*. Spatially resolved metabolomics based on air-flow-assisted desorption electrospray ionization-mass spectrometry imaging reveals region-specific metabolic alterations in diabetic encephalopathy. Journal of Proteome Research. 2021, 20(7):3567–3579. (IF: 5.4).
7. Zhonghua Wang, Bingshu He, Yaqi Liu, Meiling Huo, Wenqing Fu, Chunyan Yang, Jinfeng Wei, Zeper Abliz*, In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging. Acta Pharmaceutica Sinica B. 2020, 10(6):1083-1093. (IF: 11.6)
8. Xianyue Meng, Wenqing Fu, Meiling Huo, Yaqi Liu, Zixuan Zhang, Jinfeng Wei, Zhonghua Wang*, Zeper Abliz. In situ label-free visualization of tissue distributions of salidroside in multiple mouse organs by MALDI-MS imaging. International Journal of Mass Spectrometry, 2020, 6, 116347. (IF: 2.0)
9. Zhonghua Wang, Xiaoyu Xu, Bingshu He, Jinghua Guo, Baoxin Zhao, Yanping Zhang, Zhi Zhou, Xia Zhou, Ruiping Zhang*, Zeper Abliz*, The impact of chronic environmental metal and benzene exposure on human urinary metabolome among chinese children and the elderly population, Ecotoxicology and Environmental Safety. 2019, 169: 232-239. (IF:4.9)
10. WANG Zhong-Hua, HE Bing-Shu, SUN Cheng-Long, SONG Xiao-Wei, HE Jiu-Ming, ZHANG Rui-Ping, ZEPER Abliz*, Study on the Tissue Distribution of aVariety of Endogenous Metabolites by Air Flow Assisted Ionization-Ultra High Resolution Mass Spectrometry Imaging, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2018, 46(3): 406-412. (IF:0.9)
Patent Applications
Zaipal Abulizi, Naibi Abulaiti, Zhonghua Wang, Bing Shu He, Bing Xie
“Metabolomics-Based Quality Evaluation Method for Weiyu Kunlun Snow Chrysanthemum”
Patent Application No.: 201910639076.1 (Application Date: July 16, 2019)
Zhonghua Wang, Lulu Chen, Zhi Zhou, Bing Shu He, Zaipal Abulizi
“A Metabolomics Analysis Method for Xinjiang Artemisia Plants”
Authorized Patent No.: ZL201810128472.3 (Authorization Date: November 3, 2020)
Zhonghua Wang, Bing Shu He, Lulu Chen, Zaipal Abulizi
“A Method for Simultaneously Quantifying Astragaloside-IV and Isoastragaloside in Mouse Plasma”
Authorized Patent No.: ZL201810730008.1 (Authorization Date: April 6, 2021)
